Step Change in Solid Compound Management!
Unrivalled accuracy and precision
Pharmaceutical industry faces the increased demand for innovative medicines against various diseases. In this regard, the compound library in pharmaceutical industry is the most valuable asset. However, the compound distribution from the library into the screening plates is often still done manually and binds highly qualified resources to very time-consuming, tedious and error-prone tasks.
Chemspeed’s revolutionary SWILE automated workstation provokes a step change in compound management. In order to demonstrate its potential we performed the reformatting / dispensing of standard catalogue solid chemicals in the range of 0.5 mg to 5 mg.
Furthermore, Chemspeed developed with the same technology the SWIP – “pick & decision dispense” of liquid, oily or sticky compounds.
Description of SWILE Technology – Ultimate Decision Dispensing
The SWILE technology is the first fully automated true one-to-one gravimetric “pick & decision dispense” of compounds. The below scheme displays the simplified SWILE workflow including a precision “pick & decision dispense” step. The technology backbone is following Chemspeed’s proprietary overhead gravimetric dispensing tool design in combination with a second analytical on-deck-balance.
Accuracies and precisions are tremendously increased by this “pick & decision dispense” algorithm. The integrated balance of the SWILE tool has a resolution of 0.1 mg which actively measures during the pick-up process. This enables a controlled pick-up of the target amount prior to the actual dispense. During the latter, the on-deck-balance with a resolution of 0.01 mg is actively recording the weight of the received compound and enhances the accuracy and precision by controlling the SWILE tool. Moreover, in comparison to conventional micro dispensers no manual pre-filling of containers is needed, as a direct transfer from any kind of source (e.g. vial, tube, plate) into any kind of destination (e.g. vial, tube, plate) can be conducted.
In order to exclude any risk of cross-contamination disposable glass tips are used which are stored and provided by a SWIN dispenser. They are available in different sizes (diameter) and can be adjusted according to the desired target amount to be dispensed. Additionally, a tilt / shake rack is used which is loosening up and tilting the powder prior to the pick-up.
Typical parameters to dispense a library of compounds with different morphology
To summarize, the enter solution provides the following key features:
- Fully automated “pick & decision dispense” from almost any source into any destination.
- Dispensing range from <100 µg to 100 mg with 10 µg resolution.
- Revolutionary accuracy & precision due to “decision dispensing”.
- Disposable tips.
- No cross-contamination.
- No dead volume.
- A recovery rate equal or higher than in manual procedures.
- Unattended operation (with optional inert atmosphere).
- Boost in your R&D process and time to market.
The modular robotic platform additionally handles supporting tasks like capping / uncapping of either crimped or screw capped vials, barcode reading and tracking, agitation, dissolution, and a vast number of further options.
Interested in the step up to the next generation of compound logistics?
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