SWING CRYSTAL: Crystallization, Polymorph, Salt and Solubility Screening

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with a wide range of crystallization plates, and our user-friendly software, allow you to standardize and accelerate your crystallization experiments.

Example Customer testimonial

The principal gain over manual crystallization lies in the automated sequencing of crystallization steps, including computer controlled dosing of liquids and solids.

Key Advantages:

  • Decrease in cost per sample up to 90+ %.
  • Increase in productivity by a factor of 10+.
  • Up to 192 crystallization experiments per run can be done on MTP based and other formats.
  • Wide range of workflows: salt, polymorph, co-crystal, solubility screening (incl. agitation, pH, temperature gradients, filtration, controlled evaporation).
  • Systematically investigate the influence of critical factors such as different solvents (eluotropic series), different concentrations, rate of evaporation, temperature, cooling rate, agitation on crystal structures.
  • Run two different crystallization workflows simultaneously.
  • Highly reliable and precise gravimetric dispensing tools for liquid and solid dispensing.
  • Reproducible results.
  • Different reactor sizes (from < 1 mL to 100 mL in disposable formats and up to 1’000 mL in high-output process development reactors) allow for screening and development / scale-up on the same platform.
  • Direct output on XRPD compatible glass plates (eliminating e.g. risk of crystal damage, cross contamination by electrostatic forces due to moving the powders).
  • Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
  • Interface to DoE.

Reactors for crystallization screening (easy-to-use sandwich design with direct output to XRPD)

Reactors for crystallization screening (easy-to-use sandwich design with direct output to XRPD)

Reactor for crystallization development & scale-up

Reactors for crystallization development & scale-up

Reactor for crystallization development & scale-up

Reactors for crystallization development & scale-up

Enhance your Efficiency and Productivity with our Workflow Solutions!

Example Workflow Crystallization Screening

SWING CRYSTAL workflow crystallization screening example

Features

  • Precise gravimetric solid dispensing for handling small quantity of solids (AI).
  • 4-Needle Head for volumetric liquid handling, equipped with heated needles for hot transfer.
  • Active washing station for outside and inside rinsing of needles.
  • Multigripper tool for transporting filtration, evaporation, work-up plates on the platform.
  • Shaking racks with controlled heating / cooling (temperature range -20 to 150 oC, -70 to 200 oC with double-jacket reactors) and agitation (shaking range 100 – 1400 rpm).
  • Individual shaking racks with independent functionalities (speed, temperature).
  • Crystallization plates available in 96 and 48 MTP based formats – sandwich construction: easy to assemble and dismantle.
  • Filtration plate equipped with 96 or 48 tips with integrated semi-disposable filters and heating functionality for hot filtration.
  • Evaporation plate equipped with 96 or 48 tips allowing to evaporate the solvent in a controlled way.
  • Work-up plate for filtration to waste.
  • pH needle system for up to 4 parallel pH measurements and adjustments.

Technical Details

Chemspeed’s SWING CRYSTAL deck modularity allows the user to execute and perform a variety of crystallization, salt, polymorph and solubility screening workflows in a fully automated fashion.

Crystallization reactors range from < 1 mL to 1’000 mL

Crystallization MTP plate: < 1 mL to 2 mL

Crystallization MTP plate: < 1 mL to 2 mL

  • MTP based format 96, 48, 24.
  • Sandwich-like, o-ring-free construction with detachable glass bottom for XRPD analysis in reflection and transmission.
  • Glass plate can be placed directly on XRPD device.
  • XRPD measurements in transmission and reflection mode.

Filtration plate

Filtration Plate

  • Filtration plate with 96, 48, 24 tips with integrated semi-disposable filters for heated filtration of API solution from MP1 to MP2.
  • Fast, simultaneous filtration of 96, 48, 24 wells.

Evaporation plate

Evaporation plate

  • Evaporation plate equipped with 96, 48, 24 tips.
  • Tips standing above liquid level to evaporate the solvent in a controlled way.

Work-up plate

Work-up plate

  • Work-up plate equipped with 96, 48, 24 tips.
  • For filtration to waste after crystallization.
  • For evaporation of the solvent in a controlled way.
SCALE-UP options

Reactors for crystallization development
Reactors for crystallization development

Isynth array reactors: < 8 mL to 100 mL

Disposable glass reactors available in different sizes (8, 20, 100 mL). The reactors are inserted in a shaking
rack with heating / cooling functionality. Filter elements allow for hot filtration and filtration to waste.

Reactor for crystallization development
Reactors for crystallization development

Process reactor: 100 mL to 1’000 mL

Individually controlled process reactors (reactor volumes 100, 250, 1’000 mL) with inline filtration, stirring
control, reflux and high-precision heating / cooling (-50 to 250 oC), vacuum control (for solvent evaporation).

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