ISYNTH CATSCREEN 96: Unattended Catalyst Preparation and Screening

At Ambient and Elevated Pressure in 96 Well Plates

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our versatile, fully automated MTP pressure block equipment, and our user-friendly software, allow you to standardize and accelerate your catalysts screening in flexible well plate formats (e.g. 12, 24, 48, 96).

Example Customer testimonial

Chemspeed’s robotic platform – CATSCREEN 96 – did pay off itself within 6 months! We do screens with wider parameter space, greater control and better quality than if we would outsource the work to several companies.

The Chemspeed CATSCREEN 96 is a real workhorse with a capacity to run many hundreds of reactions/week.It enables us to rapidly generate and evaluate large numbers of catalysts for important transformations such asasymmetric hydrogenations and cross-couplings.

Key Advantages:

  • Decrease in cost per experiment up to 90+ %.
  • Increase in productivity by a factor of 10+.
  • Catalysts preparation and screening at ambient and elevated pressure in 96-well plates (1-100 bar), work-up, analysis.
  • Ventilated, conditioned hood for e.g. sensitive, low-temperature chemistry. (optional integration within customized MBraun glove-box).
  • Unique fully automated MTP pressure block technology.
  • 4-Needle Head for volumetric liquid handling and sampling.
  • Gravimetric solid dispensing into an unlimited choice of vial / plate / reactor formats.
  • The balance moves to the destination, increasing speed and efficiency.
  • Balance resolution of 100 µg, or 10 µg.
  • A large dispensing range, from a few mg up to several grams.
  • Powder dispensing / dosing robotic tool can be combined with other tools to accommodate multiple workflows.
  • Dispensed amount, mixing speed, temperature, pressure, time…, and other data are stored in a read only log file.
  • Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
  • Interface to DOE.

Enhance your Efficiency and Productivity with our Workflow Solutions!


Chemspeed’s Unique, Proprietary Array Synthesis Reactor Technology with Disposable Vials

Fully automated well-plate (pressure) screening block

Pick-up metallic MTP with e.g. 96 glass vials

Pick-up metallic MTP with e.g. 96 glass vials

Transfer plate

Transfer plate

Load plate into pressure block

Load plate into pressure block

MTP (well-plate) pressure block with screwless, self-sealing automated opening / closing

MTP (well-plate) pressure block with screwless, self-sealing automated opening / closing

Technical Details

Chemspeed’s ISYNTH CATSCREEN 96 deck modularity allows the user to execute and perform a variety of catalyst preparation and screening workflows in a fully automated fashion, incl. work-up, analysis.

MTP pressure block

MTP pressure block

mtp pressure reactor block

Pressure reactor block

MTP pressure block, 100 bar

  • Automatic pressure chamber with 1’000 mL volume for various formats.
  • Flexible reactive gas supply (e.g. H2, CO, O2, NH3).
  • Shakable, heatable, coolable.
  • Automated self-sealing closing / opening.

General details

  • Inertization box with air-lock (optional integration with MBraun glovebox).
  • O2 and H2O monitored for controlled inert gas conditions.
  • Flexible MTP format (12, 24, 48, 96) with disposable glass inserts.
  • Flexible vial and MTP transfer tool for e.g. automated transfer to / from MTP pressure block.
  • Integrated MTP stirrer.
  • Inertized stock solutions.
  • Inertized and shaken catalyst suspensions.
  • Large choice of disposable reactors.
  • Sampling for online analytics.

The 4-Needle Head for liquids

4-Needle Head

Volumetric dispensing and aspiration of liquids is done with a Multi-Channel Liquid Handling Tool (4-Needle Head), with four independent needles. The four needles can be operated simultaneously or individually. If required the tool can be equipped with needles of different inner diameters. Larger diameter needles for the handling of suspensions or liquids with higher viscosities, smaller diameter needles for handling of small volumes.

Gravimetric dispensing units for solids and powders (SWILE, SDU, GDU-P)

The Gravimetric Dispensing Units for solids and powders (SWILE, SDU, GDU-P)

The Gravimetric Dispensing Units (SWILE, SDU and GDU-P models) are used to perform automated, gravimetrically controlled dispenses of a wide range of solids and powders in the milligram to multigram scale. The modules pick the appropriate chosen container, dispense the solids and powders, and then place the container back to its station before picking the next one. Both dispensing units include an overhead balance, and allow dispensing and simultaneous weighing of solids and powders into various vials, reactors, well-plates.

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