ISYNTH SPEEDCHEM: Automated Library Synthesis in Disposable Vials / Reactors under Accelerating Superheated Conditions

The ISYNTH SPEEDCHEM uses a combination of elevated temperature and pressure to increase the reaction rate, resulting in shorter reaction times and higher selectivities.

Example Customer testimonial

Do it in the microwave “way”! But 96 instead of 1 at a time and at faster reaction rates.

Key Advantages:

  • Decrease in cost per experiment up to 90+ %.
  • Increase in productivity by a factor of 10+.
  • Increased temperature to e.g. 40°C above the boiling point results in about 16 times faster reaction at better quality.
  • Reagent preparation (liquids and solids), multistep synthesis, work-up, purification, analysis and product transfer to storage.
  • Disposable glass reactors in MTP format.
  • 4-Needle Head for volumetric liquid handling and sampling.
  • Gravimetric solid dispensing into an unlimited choice of vial / plate / reactor formats.
  • Higher reagents solubility into solvent.
  • Milder reaction conditions.
  • Less side reactions / reagent alteration and higherchemical yield.
  • Lower energy usage.
  • Exchangeable robotic tools to accommodate multiple workflows.
  • Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
  • Interface to DOE.

Enhance your Efficiency and Productivity with our Workflow Solutions!


Do it in the microwave “way”, but 96 instead of 1 at a time and at faster reaction rates.

As a rule of thumb the reaction rate doubles itself if the temperature is increased by 10°C, reactions that normally take hours can be done in minutes at better quality using ISYNTH SPEEDCHEM.

Selection of application:

  • Library synthesis.
  • Porous material synthesis .
  • Polymer synthesis.
  • Reaction parameter screening.
  • Solubility, stability, compatibility screening.
  • Sample preparation.
  • Formulation screening.

Fully automated well-plate (pressure) screening block

Pick-up metallic MTP with e.g. 96 glass vials

Pick-up metallic MTP with e.g. 96 glass vials

Transfer plate

Transfer plate

Load plate into pressure block

Load plate into pressure block

MTP (well-plate) pressure block with screwless, self-sealing automated opening / closing

MTP (well-plate) pressure block with screwless, self-sealing automated opening / closing

Technical Details

Chemspeed’s ISYNTH SPEEDCHEM deck modularity allows the user to execute and perform a variety of synthesis workflows under superheated conditions in a fully automated fashion, including reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage.

MTP pressure block
MTP pressure block

SPEEDCHEM block for 12, 24, 48 or 96 vial plates (or customized formats)
Key features:

  • Up to 100 bar operating pressure.
  • Heating / cooling and shaking.
  • Automated closing / opening combined with transfer tool for e.g. transport of vials and extraction plates.
  • Synthesis time reduced from hours to minutes.
  • Safer than using microwave.
  • Higher pressure than available microwave ovens (reactors) results in a multiple of speed – in a parallel approach – in a disposable format – resulting in high speed research at better quality.
Vial plates
Vial plates
Selection of additional possibilities:

  • Glove-box with air-lock.
  • O2 and H2O monitored for controlled inert gas.
  • Integrated MTP stirrer.
  • Inertized stock solutions.
  • Sampling for online analytics.
The 4-Needle Head for liquids
4-Needle Head
Volumetric dispensing and aspiration of liquids is done with a Multi-Channel Liquid Handling Tool (4-Needle Head), with four independent needles. The four needles can be operated simultaneously or individually. If required the tool can be equipped with needles of different inner diameters. Larger diameter needles for the handling of suspensions or liquids with higher viscosities, smaller diameter needles for handling of small volumes.
Gravimetric dispensing units for solids and powders (SWILE, SDU, GDU-P)
The Gravimetric Dispensing Units for solids and powders (SWILE, SDU, GDU-P)
The Gravimetric Dispensing Units (SWILE, SDU and GDU-P models) are used to perform automated, gravimetrically controlled dispenses of a wide range of solids and powders in the milligram to multigram scale. The modules pick the appropriate chosen container, dispense the solids and powders, and then place the container back to its station before picking the next one. Both dispensing units include an overhead balance, and allow dispensing and simultaneous weighing of solids and powders into various vials, reactors, well-plates.
Disposable glass reactor
  • In solution and on solid phase synthesis.
  • In sophisticated disposable reactor formats.
  • Under ambient and elevated pressure up to 100 bar.
  • Under inert gas or reactive gas conditions.
  • Including many work-up functions such as vacuum, filtration, evaporation, liquid / liquid extraction, crystallization.
  • Synthesis of branched and multistep protocols for library synthesis.
  • Synthesis of peptide libraries (peptide wizard software).

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