Quality by Design (QbD), Proven Accetable Range (PAR) Driven Automated Process R&D and Preparative Synthesis Solutions


The Chemspeed FLEX AUTOPLANT workstations have been designed for high output experimentation in the development and optimization of pharmaceuticals, agrochemicals, polymers, specialty chemicals, catalysts and many more.

  • Process R&D.
  • Organic and inorganic synthesis, reactions under pressure (process research, optimization and scale-up).
  • Preparative synthesis.
  • Polymer synthesis (mass-, solution-, pressure-, emulsion-polymerization).
  • Crystallization.
Technical Details

The cutting edge Process Development Workstation technology allows scientists to execute and perform a variety of workflows in a fully automated fashion and truly mimic the final industrial production process. It provides all the flexibility to optimize integrated reaction sequences, even if a complex configuration of reactors and feed vessels is required.

Process reactor assembly, individually controlled tank reactors (reactor volumes 100, 250, 1’000 mL) with precise, continuous feeds.

  • Flexible and precise continuous feeds, down to 10 μL / min.
  • Up to 8 continuous liquid, liquefied gas and / or gas feeds per reactor and additional unlimited overhead access.
  • Temperature control, 0.1 °C.
  • Pressure up to 100 bar over the entire temperature range up to 250 °C with corresponding safety installations.
  • Parallel high-performance calorimetry data.
  • Viscosity data.
  • Dean Stark water trap.
  • Distillation bridge.
  • Vacuum for different purposes: inertization, crystallization, ...
  • Interface to various in-situ probes, for example: pH, UV-VIS, IR, Raman, PSD, calorimetry.
  • Measurement of gas consumption.
  • Extraction, filtration, evaporation, crystallization, distillation.
  • Reflux.

Easily exchangeable stirrer designs (anchor, twisted blade, gas entrainment stirrers…). Powerful mixing for viscosities up to 80 Pa.s at 300 rpm and 30 Pa.s at 900 rpm with an anchor stirrer.

Paradigm Shift - Combination of Batch & Flowchemistry

The leading technology in versatile comibnation of batch & flowchemistry combined with our reactor and process excellence, and our user-friendly software, allow you to standardize and accelerate your organic process R&D workflows.

Enhance your Efficiency and Productivity with our Workflow Solutions!

  • Organic synthesis & scale-up.
  • Crystallization.
  • Ligand synthesis & scale-up.
  • Organometallic synthesis & scale-up.
  • Ziegler-Natta synthesis.
  • Polyolefin prepolymerizations, solution-, slurry-, bulk-, gas-phase, multi-stage syntheses.
  • Living / controlled, emulsion, suspension, mass polymerizations.
  • Impregnations.
  • (Mixed) oxide, zeolite syntheses.
  • Catalyst testing in batch, semi-continuous, continuous mode.
  • Nanomaterials syntheses.
  • Biomass pretreatment and conversion.

Key Advantages

  • Decrease in cost per experiment.
  • Increase in productivity.
  • Up to 12 experiments per run on an FLEX AUTOPLANT.
  • Independent control of all process parameters in each reactor with PAT like NIR, PSD, calorimetry, pH.
  • Independent and precise temperature and stirring control in each reactor.
  • Up to 8 independent gas, liquefied gas and liquid feeds per reactor.
  • Gravimetric solid and viscous liquid dispensing.
  • 4-Needle Head for volumetric liquid handling and sampling.
  • Feeding and sampling under reaction conditions.
  • Cleaning in place (e.g. automated cleaning, inserts).
  • Dispensed amount, stirrer speed, temperature, pressure, time..., and other data are stored in a read only log file.
  • Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
  • Interface to DOE.