1. Large volume liquid handler Coriolis mass flow meter Ultrasound detector
2. Small volume liquid handler pH-adjustment
3. Large volume solids handler
4. Small volume solids handler
5. Screw-capper
6. Thermo-transfer labeler

• Compliant with FDA 21 CFR part 11 guidelines
• Custom integration into IT-infrastructure
• Templates allow for efficient programming of eluent recipes
• Direct input via browser application

Key Specifications

• flowrate up to 1000 mL / min
• volumetric range 10…2000 mL
• accuracy ± 0.6%
• precision   ± 0.3%.

Not all bottles are created equal. It would great to use just Schott bottles to prepare eluents, but their large manufacturing tolerances necessitate a volumetric flask during the manual process. Our FLEX EP bypasses this transfer by calibrating every Schott bottle ad hoc: a Coriolis mass flow meter measures the water flow and adjusts the final volume with high throughput and accuracy.

Key Specifications

• distance range 60…400 mm
• accuracy ± 0.5 mm
• precision ± 0.3 mm
• response time < 60 ms
• sound frequency 400 kHZ

In a second step, the liquid level is measured with an ultrasound detector. This value is saved as a reference for a subsequent step, where the final eluent volume will be compensated up to this level.

Key Specifications

• Four ambient pressure syringe pumps
• PTFE tubing from the syringe pumps to the needles
• Rinsing station for automatic cleaning of needles and lines
• Four independent septum-piercing steel needles
• inner diameter 0.8 mm
• length 292 mm
• volumetric range 2.5…10 mL
• accuracy ± 0.8%
• precision ± 0.3%
• volumetric range 10…100 mL
• accuracy ± 0.6%
• precision ± 0.3%

The 4-Needle Head (4-NH) has two functions: it removes water to make space for the eluent’s ingredients and adds other liquid components to the eluent. The 4-NH is resistant to chemicals and designed for precise handling of organic solutions. The self-cleaning routines can be programmed freely.

Key Specifications

• pH range 0…14
• zero point (pH) 7.00 ± 0.25
• resolution 0.05
• temperature range 0…80 °C
• shaft material glass
• membrane glass LoT
• membrane resistance (25°C) < 600 mΩ
• Temperature probe NTC 30 kΩ

The pH can be measured and adjusted if needed.  Calibration of the analytical sensor is carried out automatically in defined time intervals. Pre-filled bottles with acids and bases are stored inside the system.

Key Specifications

• nominal balance accuracy 1 mg
• number of containers 12
• storage capacity per container 100 mL
• total storage volume 1’200 mL

Salts and other powders are dispensed by two gravimetric dispensing units (GDU-P and GDU-Pfd). All solids are stored in GDU-containers, automatically picked up by the GDU and dispensed directly into Schott bottles. The GDU-P is built for fast dispenses of larger quantities while the GDU-Pfd allows for a high accuracy. The system decides autonomously, which balance to use in order to maximize throughput while adhering to the specified accuracy.