High-Throughput Library Synthesis with online NMR (e.g. automated synthesis and characterization of innovative medicines)

FLEX ISYNTH Library Synthesis with online NMR

Facing challenges like

Medicinal chemistry is driven more and more by the demand for innovative medicines which involves molecular diversity and novel routes, meaning more and more experiments typically with the same resources.

Chemspeed’s fully automated, integrated FLEX ISYNTH stands for a flexible, modular, and uncompromising automated solution that:

  • Unlocks the chemical space via faster, better, virtually unrestricted “off-road” chemistry investigation of the reaction, reagent and molecule space.
  • Enhances your efficiency and productivity by a factor of up to 100 in e.g.:
    • C-C, C-N coupling reactions
    • Organometallic reactions (e.g. Grignard)
    • Alkylations
    • Diels-Alder reactions
    • Transfer hydrogenations

Reactor arrays
  • Easy-to-use disposable multi-functional, high-precision glass reactor arrays:
    • Available reaction scales from μl to ml
    • Screwless and self-sealing opening / closing
    • Mixing by shaking (up to 600 rpm)
    • Heating (up to 150°C), cooling (-20°C)
    • Refluxing, vacuum, inertization, evaporation, extraction, filtration, crystallization and drying
  • Chemistry proven liquid handling with e.g. pH, filtration extension.
  • Proprietary robotic tool exchange for e.g. gravimetric solid handling.


Integrated Benchtop NMR

  • Available operating frequency range: 40 MHz to 80 MHz (1H)
  • Available nuclei: H, F, C, P, Si, B
  • 1D and 2D spectra
  • Online data acquisition via flow cell or offline via standard 5 mm sample tubes
  • Permanent magnet - no liquid nitrogen or helium required
  • 2 Gauss line inside NMR device housing


  • Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid- and liquid-phase library synthesis
  • Throughput, up to 48 / 96 parallel reactions per run based
  • Integrated liquid handling and sampling
  • Ventilated hood for safety and conditioned operation, trolley
  • Optimized footprint (3x3 ft, 90x90 cm) versus capacity... all while reducing coats / maximising return on investment


Chemspeed’s AUTOSUITE User Interface & Executor software packages execute and control all modules of the entire product development cycle. They control all Chemspeed robotic platforms and any other integrated 3rd party software and hardware.

AUTOSUITE is a software with a user friendly interface which allows easy workflow orienteted programming. Many features such as gravimetric dispensing are automatically calibrated, eliminating tedious optimization steps.

  • The AutoTeaching tool simplifies dispensing applications without manual trials and is applicable to e.g. solids eliminating the need for manual optimization before the dispenses are done.
  • Easy programming: drag-and-drop workflow steps or just execute standard workflow protocols.
  • Barcode tracking.
  • ARKSUITE Workflow Studio and Internet of the Lab Tools (e.g. DoE, data mgt, substance parameter database, inventory mgt, product mgt, run mgt) includes a full document management system (electronic labjournal) and is 21 CFR Part
    11 compliant. The software scales from a single PC to large network / cloud installations with multiple hardware and clients.

Optional features

  • Proprietary high-precision overhead gravimetric dispensing of solids and liquids
  • Cooling
  • pH measurement
  • On-line analysis (e.g. injection valves for HPLC (-MS))
  • Workup (e.g. SPE and filtration racks)