Step Change in End-to-End NMR and LCMS Sample Preparation - Gravimetric Pick & Decision Dispense of Solids (incl. applications in GMP environments)


Nuclear magnetic resonance (NMR) is a method of physical observation in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field and therefore not involving electromagnetic waves) and respond by producing an electromagnetic signal with a frequency characteristic of the magnetic field at the nucleus.
NMR results from specific magnetic properties of certain atomic nuclei. Nuclear magnetic resonance spectroscopy is widely used to determine the structure of organic molecules in solution and study molecular physics, crystals as well as non-crystalline materials. NMR is also routinely used in advanced medical imaging techniques, such as in magnetic resonance imaging (MRI). However, the preparation of NMR samples is often still done manually and binds highly
qualified resources to very time-consuming, tedious and error-prone tasks.

SWILE dispensing solutions

The SWILE technology allows automated true one-to-one gravimetric "pick & decision dispense" of compounds.
The scheme at the bottom of this page displays the simplified SWILE workflow including a precision "pick & decision dispense" step. The technology backbone is following Chemspeed’s proprietary overhead gravimetric dispensing tool design in combination with a second analytical on-deck-balance.

Dispensing characteristics

In order to exclude any risk of cross-contamination disposable glass tips are used which are stored and provided by a SWIN dispenser. The SWINS are available in different sizes (diameter) and can be adjusted according to the desired target amount to be dispensed. Additionally, a tilt / shake rack is used to loosening up and tilt the powder prior to pick-up.

  • Revolutionary accuracy & precision due to decision dispensing.
  • Dispensing range from <100 μg to 100 mg with +/- 10 μg resolution.
  • No cross-contamination.
  • No dead volume.
  • Unattended operation.
  • Fully inert (glass).

Pick & Decision dispense

FLEX SWILE solution for NMR sample preparation
  • Proprietary robotic tool exchange interface.
  • Ventilated hood for safety, trolley.
  • Optimized footprint (3x3 ft, 90x90 cm) versus capacity - all while reducing costs and maximizing return on investment.
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface to DoE and data analysis.
  • Application programming interface for e.g. LIMS, ELN integration.
  • SWILE Robotic Tool can be combined with other tools to accommodate multiple workflows.
  • On-deck balance, tilt / shake rack, barcode reader, multigripper.
  • Automated sample dispensing into NMR tubes and LC vials (optional on-deck balance for +/- 10 μg resolution).