Paradigm Shift - Combination of Automated Batch & Flowchemistry


Paradigm shift - combination of automated batch & flowchemistry

The leading technology in versatile combination of autoamted batch & flowchemistry combined with our quality by design reactor and process excellence, and our user-friendly software, allow you to accelerate, standardize and digitalize your organic process R&D workflows.

Key advantages

  • Decrease in cost per experiment up to 90+ %.
  • Increase in productivity by a factor of 10+.
  • Up to 36 experiments per run on an AUTOPLANT, up to 12 experiments per run on a FLEX.
  • Combination of batch & flowchemistry.
  • Independent and precise process parameter control in each reactor (such as feed / flow, temperature, mixing).
  • Independent gas, liquefied gas and liquid feeds.
  • Gravimetric solid and (viscous) liquid dispensing.
  • 4-Needle Head for volumetric liquid handling and sampling.
  • PAT like IR, PSD, calorimetry, pH.
  • Feeding and sampling under reaction conditions.
  • Reaction under reflux at ambient pressure with optional Dean Stark water removal or distillation.
  • Reactions at elevated pressure.
  • Vessel-to-vessel transfer for multistep reactions.
  • Workup with liquid / liquid extraction, drying, solid-phase extraction, filtration or evaporation.
  • Cleaning in place (e.g. automated cleaning, inserts).
  • Dispensed amount, stirrer speed, temperature, pressure, time..., and other data are stored in a read only log file.
  • Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
  • Interface to DoE.

Enhance your efficiency and productivity with our workflow solutions!
Technical details

Chemspeed’s AUTOPLANT FLOWCHEM deck modularity allows the user to execute and perform a variety of workflows in a fully or semi-automated fashion.

The synthesis of most organic compounds includes the following steps which can all be fully automated on the AUTOPLANT:

  • Interface to DoE.
  • Addition of liquid and / or solid reagents.
  • Reaction in continuous flow.
  • Reaction under reflux at ambient with optional Dean Stark water removal or distillation or elevated pressure.
  • PAT
  • Vessel-to-vessel transfer for multistep reactions.
  • Work-up with liquid / liquid extraction, drying, solid-phase extraction, filtration
    or evaporation.
  • Product isolation.
  • Analysis.
  • Cleaning in place