Quality by Design (QbD), Proven Accetable Range (PAR) Driven Automated Process R&D - Optimization and Scale-Up


MULTIPLANT / AUTOPLANT PRORES

Reaction preparation, synthesis, work-up, analysis

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Robustness and ease-of-use by design - Each reactor with its own set of conditions

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our quality by design reactor technology and process excellence, and our user-friendly software, allow you to accelerate, standardize, and accelerate your organic process R&D workflows.

Key advantages

  • Decrease in cost per experiment up to 90+ %.
  • Increase in productivity by a factor of 10+.
  • Up to 36 experiments per run on an AUTOPLANT, up to 6 experiments per run
    on a MULTIPLANT.
  • Independent control of all process parameters in each reactor with PAT like NIR, PSD, calorimetry, pH.
  • Independent and precise temperature and stirring control in each reactor.
  • Up to 8 independent gas, liquefied gas and liquid feeds per reactor.
  • Gravimetric solid and viscous liquid dispensing.
  • 4-Needle Head for volumetric liquid handling and sampling.
  • Feeding and sampling under reaction conditions.
  • Reaction under reflux at ambient or elevated pressure with optional Dean Stark water removal or distillation.
  • pH monitoring and control.
  • Vessel-to-vessel transfer for multistep reactions.
  • Workup with liquid / liquid extraction, drying, solid-phase extraction, filtration or evaporation.
  • Cleaning in place (e.g. automated cleaning, inserts).
  • Dispensed amount, stirrer speed, temperature, pressure, time..., and other data are stored in a read only log file.
  • Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
  • Interface to DoE.

Enhance your efficiency and productivity with our workflow solutions!
Assembly of a process research reactor with our unique screwless and self-sealing design up to 100 bar

The cutting edge Process Development Workstation Technology allows scientists to truly mimic
the final industrial production process and provides all the flexibility to optimize integrated reaction sequences, even if a complex configuration of reactors and feed vessels required.

Process reactor assembly, individually controlled tank reactors (reactor volumes 100, 250, 1’000 mL) with precise, continuous feeds.

  • Flexible and precise continuous feeds, down to 10 μL / min.
  • Up to 8 continuous liquid, liquefied gas and / or gas feeds per reactor and additional unlimited overhead access.
  • Accurate and reproducible temperature control, 0.1 °C.
  • Pressure up to 100 bar over the entire temperature range up to 250 °C with corresponding safety installations.
  • Parallel high-performance calorimetry data.
  • Viscosity data.
  • Dean Stark water trap.
  • Distillation bridge between 2 reactors.