Quality by Design (QbD), Proven Accetable Range (PAR) Driven Automated Process R&D - Optimization and Scale-Up


MULTIPLANT / AUTOPLANT PRORES

Reaction preparation, synthesis, work-up, analysis

Robustness and ease-of-use by design - Each reactor with its own set of conditions

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our quality by design reactor technology and process excellence, and our user-friendly software, allow you to accelerate, standardize, and accelerate your organic process R&D workflows.

Key advantages

  • Decrease in cost per experiment up to 90+ %.
  • Increase in productivity by a factor of 10+.
  • Up to 36 experiments per run on an AUTOPLANT, up to 6 experiments per run
    on a MULTIPLANT.
  • Independent control of all process parameters in each reactor with PAT like NIR, PSD, calorimetry, pH.
  • Independent and precise temperature and stirring control in each reactor.
  • Up to 8 independent gas, liquefied gas and liquid feeds per reactor.
  • Gravimetric solid and viscous liquid dispensing.
  • 4-Needle Head for volumetric liquid handling and sampling.
  • Feeding and sampling under reaction conditions.
  • Reaction under reflux at ambient or elevated pressure with optional Dean Stark water removal or distillation.
  • pH monitoring and control.
  • Vessel-to-vessel transfer for multistep reactions.
  • Workup with liquid / liquid extraction, drying, solid-phase extraction, filtration or evaporation.
  • Cleaning in place (e.g. automated cleaning, inserts).
  • Dispensed amount, stirrer speed, temperature, pressure, time..., and other data are stored in a read only log file.
  • Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
  • Interface to DoE.

Enhance your efficiency and productivity with our workflow solutions!
Assembly of a process research reactor with our unique screwless and self-sealing design up to 100 bar