Take your classical synthesis to hyper speed

SMOLE 2022

  • Productivity increase by a factor of 1'000 and more
  • 96 / 384 reactions at a time
  • Step-change in quality increase


Life science industry faces the increased demand for innovative, “Rule of five compatible small-molecule” medicines against various diseases. Time-to-market with an easily accessible but highly innovative API is essential.

Gamification of Research & Development represents a paradigm shift in life science research. It enables flexibility, diversity, standardization, and speed in the entire discovery process, i.e. synthesis, purification, sample management, reformatting and biology testing, based on an unprecedented automation concept combined with SMOLE.


Is a disruptive, easy-to-use, standardized and ready-to-apply chemicals consumables technology - Gamification of Medicinal Chemistry, enabling innovative medicines by increased productivity, quality and inspiration.

It is a unique and revolutionary concept for compound handling and reaction preparation by providing prefilled chemicals in various fixed molarities in sealed and crushable glass ampules/PINs (e.g. 5.00, 2.00, 1.00, 0.50, 0.20, 0.10, 0.05, 0.02, 0.01 mmol).


Application examples SMOLE

Add your chemicals in an organic synthetic reaction with “chemical coins”, as flexible, safe, reliable and convenient as you pay for your coffee.

More possibilities available than in classical synthesis:
SMOLE - Key benefits at a glance
  • Disruptive hardware digitalization - convenient and exciting (“3D Nespresso”)
  • Homogeneity of compound matrix
  • Compatible with manual and (semi-)automated synthesis equipment
  • Enabling combinatorial and μg-chemistry
  • Enabling new possibilities in experimental chemistry (e.g. libraries of sensitive catalysts) – brings the glovebox into the reactor
  • Enables remote controlled reactions eliminating scheduling challenges
  • Low entry barrier - fully compatible with researchers’ classical work routines
  • Safety increased as storage of chemicals and handling of hazardous compounds is performed in a clean and self-contained manner
  • Quality increase step-change through elimination of error-prone calculations & handling with enhanced scientific significance due to higher reagent and reaction quality
  • Inventory cost savings - costly waste management is significantly reduced
  • Time saving


SMOLE - A condensed workflow