Step-Change in Solid Reformatting / Distribution


SWILE

Unique matrix-to-matrix / mother-to-daughter solid reformatting enabled by our gravimetic pick & decision dispense (SWILE) from virtually any source into any destination

Robustness and ease-of-use by design

SWILE solid dispensing / dosing technology combined with our patented overhead gravimetric
capability and our user-friendly software, allow you to automatically “pick & decision dispense”
solid compounds directly from almost any source into any destination. 

Precision – Speed – Accuracy
Performance – Versatility 
R&D Cost Savings – High-Throughput

"Compound management - the safe of pharma industry"

Pharmaceutical industry faces the increased demand for innovative medicines against various
diseases. In this regard, the compound library in pharmaceutical industry is the most valuable asset.
However, the compound distribution from the library into the screening plates is often still done
manually and binds highly qualified resources to very time-consuming, tedious and error-prone
tasks.

Enhance your efficiency and productivity with our workflow solutions!
Key advantages

  • Key Features: Revolutionary accuracy & precision due to decision dispensing.
  • Automated “pick & decision dispense” from almost any source into any destination. Dispensing range from < 100 μg to 100 mg with +- 10 μg resolution.
  • Disposable glass tips (SWINs).
  • No cross-contamination.
  • No dead volume.
  • A recovery rate equal or higher than in manual procedures.
  • Unattended operation (with optional inert atmosphere).
  • Boost in your R&D process and time to market.

Breakthrough dispensing technology - ultimate decision dispensing

The SWILE technology is the first fully automated true one-to-one gravimetric "pick & decision
dispense" of compounds. The below scheme displays the simplified SWILE workflow including
a precision "pick & decision dispense" step. The technology backbone is following Chemspeed’s
proprietary overhead gravimetric dispensing tool design in combination with a second analytical ondeck-balance.

Accuracies and precisions are tremendously increased by this "pick & decision dispense" algorithm. The integrated balance of the SWILE tool has a resolution of 0.1 mg which actively measures during the pick-up process. This enables a controlled pick-up of the target amount prior to the actual dispense.

During the latter, the on-deck-balance with a resolution of 0.01 mg is actively recording the weight of the received compound and enhances the accuracy and precision by controlling the SWILE tool. In comparison to conventional micro dispensers no manual pre-filling of containers is needed, as a direct transfer from any kind of source (e.g. vial, tube, plate) into any kind of destination (e.g. vial, tube, plate) can be conducted.

In order to exclude any risk of cross-contamination disposable glass tips are used which are stored and provided by a SWIN dispenser.
They are available in different sizes (diameter) and can be adjusted according to the desired target amount to be dispensed. Additionally, a tilt / shake rack is used which is loosening up and tilting the powder prior to the pick-up.

Technical details

Chemspeed’s SWILE Compound Management deck modularity allows the user to execute and perform a variety of solid and powder dispensing workflows in a fully automated fashion.

The Gravimetric Dispensing Units (SWIle, SWIP, GDU-P Fine Dosing, GDU-P, GDU-HV, GDU-V models) are used to perform automated, gravimetrically controlled dispenses of a wide range of ingredients in the sub-milligram to multigram scale.

Furthermore, Chemspeed developed with the same technology the SWIP - “pick & decision
dispense” of liquid, oily or sticky compounds.

Typical parameters to dispense a library of compounds with different morphology

4 dimensions of modularity and flexibility

  • Individual platform configuration tailored to your workflow with market-proven offthe-shelf components.
  • Robotic platforms which can be easily integrated into other systems to enable multi-workflow processes (e.g. Formulation, Application and Testing procedures all integrated in a single platform).