SWING CRYSTAL

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with a wide range of crystallization plates, and our user-friendly software, allow you to standardize and accelerate your crystallization experiments.

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  • Decrease in cost per sample up to 90+ %.
  • Increase in productivity by a factor of 10+.
  • Up to 192 crystallization experiments per run can be done on MTP based and other formats.
  • Wide range of workflows: salt, polymorph, co-crystal, solubility screening (incl. agitation, pH, temperature gradients, filtration, controlled evaporation).
  • Systematically investigate the influence of critical factors such as different solvents (eluotropic series), different concentrations, rate of evaporation, temperature, cooling rate, agitation on crystal structures.
  • Run two different crystallization workflows simultaneously.
  • Highly reliable and precise gravimetric dispensing tools for liquid and solid dispensing.
  • Reproducible results.
  • Different reactor sizes (from < 1 mL to 100 mL in disposable formats and up to 1’000 mL in high-output process development reactors) allow for screening and development / scale-up on the same platform.
  • Direct output on XRPD compatible glass plates (eliminating e.g. risk of crystal damage, cross contamination by electrostatic forces due to moving the powders).
  • Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
  • Interface to DoE.

Reactors for crystallization screening (easy-to-use sandwich design with direct output to XRPD)

Reactors for crystallization screening (easy-to-use sandwich design with direct output to XRPD)

Reactor for crystallization development & scale-up

Reactors for crystallization development & scale-up

Reactor for crystallization development & scale-up

Reactors for crystallization development & scale-up

Enhance your Efficiency and Productivity with our Workflow Solutions!

Example Workflow Crystallization Screening

SWING CRYSTAL workflow crystallization screening example

Features

  • Precise gravimetric solid dispensing for handling small quantity of solids (AI).
  • 4-Needle Head for volumetric liquid handling, equipped with heated needles for hot transfer.
  • Active washing station for outside and inside rinsing of needles.
  • Multigripper tool for transporting filtration, evaporation, work-up plates on the platform.
  • Shaking racks with controlled heating / cooling (temperature range -20 to 150 oC, -70 to 200 oC with double-jacket reactors) and agitation (shaking range 100 – 1400 rpm).
  • Individual shaking racks with independent functionalities (speed, temperature).
  • Crystallization plates available in 96 and 48 MTP based formats – sandwich construction: easy to assemble and dismantle.
  • Filtration plate equipped with 96 or 48 tips with integrated semi-disposable filters and heating functionality for hot filtration.
  • Evaporation plate equipped with 96 or 48 tips allowing to evaporate the solvent in a controlled way.
  • Work-up plate for filtration to waste.
  • pH needle system for up to 4 parallel pH measurements and adjustments.

Customer testimonial

“The principal gain over manual crystallization lies in the automated sequencing of crystallization steps, including computer controlled dosing of liquids and solids.”