SWING CRYSTAL

• Decrease in cost per sample up to 90+ %.
• Increase in productivity by a factor of 10+.
• Up to 192 crystallization experiments per run can be done on MTP based and other formats.
• Wide range of workflows: salt, polymorph, co-crystal, solubility screening (incl. agitation, pH, temperature gradients, filtration, controlled evaporation).
• Systematically investigate the influence of critical factors such as different solvents (eluotropic series), different concentrations, rate of evaporation, temperature, cooling rate, agitation on crystal structures.
• Run two different crystallization workflows simultaneously.
• Highly reliable and precise gravimetric dispensing tools for liquid and solid dispensing.
• Reproducible results.
• Different reactor sizes (from < 1 mL to 100 mL in disposable formats and up to 1’000 mL in high-output process development reactors) allow for screening and development / scale-up on the same platform.
• Direct output on XRPD compatible glass plates (eliminating e.g. risk of crystal damage, cross contamination by electrostatic forces due to moving the powders).
• Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
• Interface to DoE.

Enhance your Efficiency and Productivity with our Workflow Solutions!

Example Workflow Crystallization Screening

Features

• Precise gravimetric solid dispensing for handling small quantity of solids (AI).
• 4-Needle Head for volumetric liquid handling, equipped with heated needles for hot transfer.
• Active washing station for outside and inside rinsing of needles.
• Multigripper tool for transporting filtration, evaporation, work-up plates on the platform.
• Shaking racks with controlled heating / cooling (temperature range -20 to 150 oC, -70 to 200 oC with double-jacket reactors) and agitation (shaking range 100 – 1400 rpm).
• Individual shaking racks with independent functionalities (speed, temperature).
• Crystallization plates available in 96 and 48 MTP based formats – sandwich construction: easy to assemble and dismantle.
• Filtration plate equipped with 96 or 48 tips with integrated semi-disposable filters and heating functionality for hot filtration.
• Evaporation plate equipped with 96 or 48 tips allowing to evaporate the solvent in a controlled way.
• Work-up plate for filtration to waste.
• pH needle system for up to 4 parallel pH measurements and adjustments.

Customer testimonial

“The principal gain over manual crystallization lies in the automated sequencing of crystallization steps, including computer controlled dosing of liquids and solids.”