- Decrease in cost per sample up to 90+ %.
- Increase in productivity by a factor of 10+.
- Up to 192 crystallization experiments per run can be done on MTP based and other formats.
- Wide range of workflows: salt, polymorph, co-crystal, solubility screening (incl. agitation, pH, temperature gradients, filtration, controlled evaporation).
- Systematically investigate the influence of critical factors such as different solvents (eluotropic series), different concentrations, rate of evaporation, temperature, cooling rate, agitation on crystal structures.
- Run two different crystallization workflows simultaneously.
- Highly reliable and precise gravimetric dispensing tools for liquid and solid dispensing.
- Reproducible results.
- Different reactor sizes (from < 1 mL to 100 ml in disposable formats and up to 1’000 ml in high-output process development reactors) allow for screening and development / scale-up on the same platform.
- Direct output on XRPD compatible glass plates (eliminating e.g. risk of crystal damage, cross contamination by electrostatic forces due to moving the powders).
- Easy access to data with a convenient interface to pull results into Excel or virtually any other software.
- Interface to DoE.
Reactors for crystallization screening (easy-to-use sandwich design with direct output to XRPD)
Reactors for crystallization development & scale-up
Reactors for crystallization development & scale-up
Enhance your Efficiency and Productivity with our Workflow Solutions!
Example Workflow Crystallization Screening
Features
- Precise gravimetric solid dispensing for handling small quantity of solids (AI).
- 4-Needle Head for volumetric liquid handling, equipped with heated needles for hot transfer.
- Active washing station for outside and inside rinsing of needles.
- Multigripper tool for transporting filtration, evaporation, work-up plates on the platform.
- Shaking racks with controlled heating / cooling (temperature range -20 to 150 oC, -70 to 200 oC with double-jacket reactors) and agitation (shaking range 100 – 1400 rpm).
- Individual shaking racks with independent functionalities (speed, temperature).
- Crystallization plates available in 96 and 48 MTP based formats – sandwich construction: easy to assemble and dismantle.
- Filtration plate equipped with 96 or 48 tips with integrated semi-disposable filters and heating functionality for hot filtration.
- Evaporation plate equipped with 96 or 48 tips allowing to evaporate the solvent in a controlled way.
- Work-up plate for filtration to waste.
- pH needle system for up to 4 parallel pH measurements and adjustments.
Customer testimonial
“The principal gain over manual crystallization lies in the automated sequencing of crystallization steps, including computer controlled dosing of liquids and solids.”