FLEX SWILE compound management

Step-change in solid compound management - gravimetric pick & dispense of solids for e.g. biological screening.
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Overview

Pharmaceutical industry faces the increased demand for innovative medicines against various diseases. In this regard, the compound library in pharmaceutical industry is the most valuable asset. 

However, the compound distribution from the library into the screening plates is often still done manually and binds highly qualified resources to very time-consuming, tedious, and error-prone tasks.

The SWILE technology provides fully automated true one-to-one gravimetric "pick & decision dispense" of solid compounds. The scheme at the bottom of this page displays the simplified SWILE workflow including a precision "pick & decision dispense" step. The technology backbone is based on Chemspeed’s proprietary overhead gravimetric dispensing tool design in combination with a second analytical on-deck-balance.

In order to exclude any risk of cross-contamination disposable glass tips are used which are stored and provided by the SWIN dispenser. The SWINs are available in different sizes (diameter) and can be adjusted according to the desired target amount to be dispensed. Additionally, a tilt / shake rack is used to loosening up and tilting the solid prior to pick-up.

  • Revolutionary accuracy & precision due to decision dispensing
  • Dispensing range from 100’s μg to about 5 mg with +/- 10 μg resolution
  • No cross-contamination
  • No dead volume
  • Unattended operation
  • Fully inert (glass)
Flex Matrix
Workflow

FLEX SWILE compound management

Migrated workflow: FLEX SWILE compound management
Benefits
  • Proprietary robotic tool exchange interface.
  • Ventilated hood for safety as well as conditioned operation and trolley.
  • Optimized footprint (3x3 ft, 90x90 cm) versus capacity - all while reducing costs and maximizing return on investment.
  • Application programming interface for e.g. LIMS, ELN integration.
  • SWILE Robotic Tool can be combined with other tools to accommodate multiple workflows.
  • On-deck balance, tilt / shake rack, barcode reader, multigripper.
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface to data analysis.
  • Interface for e.g. LIMS, ELN integration.

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