example solution
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Automated reaction screening (μL to mL scale)

ISYNTH REACTSCREEN for reaction screening
Automated small-molecule reaction screening (μL to mL scale) in e.g. late-stage drug discovery / lead optimization.
Overview

Chemspeed's solution

Our overhead gravimetric (patented) dispensing of solids & liquids combined with our fully automated small-scale reactor formats (μL to mL scale) and our user-friendly software boost you to accelerate, standardize and digitize your small-molecule reaction screening (incl. reaction preparation, photochemistry, work-up, analysis). 

Workflow

Example workflow

The interactive workflow panel below showcases example workflows for this solution. Each Chemspeed tool or module performs a set of specific actions, as in any manual lab workflow, and an almost limitless arrangement of these tools is possible.

ISYNTH REACTSCREEN

Details
💡 Click on a workflow node to see more details in this details panel.
Benefits

Powerful advantages

  • Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid-phase and liquid-phase μL and mL reaction screening.
  • E.g. easy-to-use SBS-plate based disposable multi-functional, high-precision glass reactor arrays with μL reaction scale, screwless and self-sealing opening / closing, mixing by shaking (up to 1'000 rpm), heating (up to 150°C) and cooling (-20°C).
  • Work-up such as evaporation, L/L extraction, filtration, solid-phase extraction, crystallization and drying.
  • Proprietary robotic tool exchange.
  • Gravimetric solid handling from μg to g.
  • Gravimetric liquid handling from mg to g / μL to mL.
  • Chemistry proven liquid handling with e.g. pH, filtration, heated needle extension.
  • Throughput, e.g. 24 / 48 / 96 / ... parallel reactions per run based.
  • Sampling and various integrated analytics such as benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell.
  • Ventilated hood for safety and conditioned operation.
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.
  • Optional integrated online benchtop NMR - including but not limited to 80 MHz Fourier RxnLite, NMR device, sample injection port, software with advanced chemical profiling and hardware integration, H / F / C / P / Si / B, 1D and 2D spectra, online data acquisition via flow cell or offline via standard 5 mm sample tubes, permanent magnet - no liquid nitrogen or helium required, 2 Gauss line inside NMR device housing
Software

AUTOSUITE

Chemspeed’s AUTOSUITE software packages execute and control all modules in every solution. They control all Chemspeed robotic platforms and any other integrated 3rd-party software and hardware.

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