ISYNTH SWAVE for MW-assisted synthesis

Automated microwave assisted synthesis and sample treatment.

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Overview

High throughput MW-assisted library synthesis (e.g. small molecules, polymers, porous materials, cathode materials) with Chemspeed’s exchangeable robotic tools for gravimetric liquid handling, gravimetric solid dispensing, capping, de-capping, crimping and gripping, combined with e.g. Biotage, microwave technology.

Workflow

ISYNTH SWAVE

Migrated workflow: ISYNTH SWAVE

Benefits

High troughput microwave assisted synthesis and treatment.
Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid-phase and liquid-phase μL and mL reaction screening.
Reagent preparation to capping/crimping/gripping, multistep synthesis, work-up, online transfer and analytics.
Work-up such as evaporation, L/L extraction, filtration, solid-phase extraction, crystallization and drying.
Proprietary robotic tool exchange.
Gravimetric solid handling from μg to g.
Gravimetric liquid handling from mg to g / μL to mL.
Chemistry proven liquid handling with e.g. pH, filtration, heated needle extension.
Throughput, e.g. 24 / 48 / 96 / ... parallel reactions per run based.
Sampling and various integrated analytics such as benchtop online NMR, HPLC (MS), UPLC (MS), GC (MS), UV-VIS, NIR / MIR / DLS measurement cell.
Ventilated hood for safety and conditioned operation.
AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface (e.g. python custom device) to e.g. LIMS, ELN, data analysis, AI / ML closed loop.
Optional integrated online benchtop NMR - including but not limited to 80 MHz Fourier RxnLite, NMR device, sample injection port, software with advanced chemical profiling and hardware integration, H / F / C / P / Si / B, 1D and 2D spectra, online data acquisition via flow cell or offline via standard 5 mm sample tubes, permanent magnet - no liquid nitrogen or helium required, 2 Gauss line inside NMR device housing