First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates

Villeneuve d’Ascq Cedex / Paris, France First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates “For the first time, the asymmetric hydrogenation of quinoxaline-2-carboxylates was performed successfully. The best catalysts are based on iridium complexes modified by chiral phosphorous ligands. Accelerated examination of ligands and catalysts has been undertaken by using a Chemspeed workstation, which enables carrying out, in parallel, eight independent catalytic reactions at the laboratory scale. Tetrahydroquinoxaline-2-carboxylates could be obtained with high yields and up to 74% ee.” For details: First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates Anna M. Maj^a,*, Svetlana Heyte^b, Marcia Araque^b, Franck Dumeignil^b,c, Sébastien Paul^b, Isabelle Suisse^a,*, Francine Agbossou-Niedercorn^{a,* a} UCCS (Unité de Catalyse et de Chimie du Solide UMR 8181), CNRS, Université de Lille, ENSCL, Cité Scientifique, CS 90108, 59652 Villeneuve d’Ascq Cedex, France ^b UCCS (Unité de Catalyse et de Chimie du Solide UMR 8181), CNRS, Université de Lille, Ecole Centrale de Lille, Cité Scientifique, CS 20048, 59652 Villeneuve d’Ascq Cedex, France ^c Institut Universitaire de France, 103 Boulevard Saint-Michel, 75005 Paris, France * Corresponding authors Tetrahedron, Volume 72, Issue 10, 10 March 2016, Pages 1375–1380