Villeneuve d’Ascq Cedex / Paris, France First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates “For the first time, the asymmetric hydrogenation of quinoxaline-2-carboxylates was performed successfully. The best catalysts are based on iridium complexes modified by chiral phosphorous ligands. Accelerated examination of ligands and catalysts has been undertaken by using a Chemspeed workstation, which enables carrying out, in parallel, eight independent catalytic reactions at the laboratory scale. Tetrahydroquinoxaline-2-carboxylates could be obtained with high yields and up to 74% ee.” 
For details: First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates Anna M. Maja,*, Svetlana Heyteb, Marcia Araqueb, Franck Dumeignilb,c, Sébastien Paulb, Isabelle Suissea,*, Francine Agbossou-Niedercorna,* a UCCS (Unité de Catalyse et de Chimie du Solide UMR 8181), CNRS, Université de Lille, ENSCL, Cité Scientifique, CS 90108, 59652 Villeneuve d’Ascq Cedex, France b UCCS (Unité de Catalyse et de Chimie du Solide UMR 8181), CNRS, Université de Lille, Ecole Centrale de Lille, Cité Scientifique, CS 20048, 59652 Villeneuve d’Ascq Cedex, France c Institut Universitaire de France, 103 Boulevard Saint-Michel, 75005 Paris, France * Corresponding authors Tetrahedron, Volume 72, Issue 10, 10 March 2016, Pages 1375–1380
Selective hydrogenation plays a critical role in modern synthetic chemistry, particularly in the pharmaceutical industry, where the production of chiral molecules with high enantiomeric purity is essential for the efficacy and safety of active pharmaceutical ingredients (APIs).
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