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Institute of Biomaterial Science and Center for Regenerative Therapies (Helmholtz-Zentrum Geesthacht) reports on High-Throughput Synthesis and Characterization of Polymer Libraries with Chemspeed’s Fully Automated SYNTHESIZER

August 4, 2014

Diffuse reflectance FTIR (DRIFT) was established as a high throughput characterization method for classic copolymer systems. Four different methyl methacrylate-based polymer libraries with styrene, N-vinylpyrrolidone, 4-vinylpyridine, or 2-carboxyethyl acrylate as comonomers were synthesized using an automated/robotic synthesizer platform, and analyzed by ¹H NMR and DRIFT. By multivariate data analysis both data sets were compared and correlations with R² between 0.9373 and 0.9971 could be achieved. By this means high throughput screening of comonomer contents of these polymer libraries was enabled.

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