First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates

Tetrahedron, Prof. Sébastien Paul, Université de Lille First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates For the first time, the asymmetric hydrogenation of quinoxaline-2-carboxylates was performed successfully. The best catalysts are based on iridium complexes modified by chiral phosphorous ligands. Accelerated examination of ligands and catalysts has been undertaken by using a Chemspeed workstation, which enables carrying out, in parallel, eight independent catalytic reactions at the laboratory scale. Tetrahydroquinoxaline-2-carboxylates could be obtained with high yields and up to 74% ee. For details: First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates Anna M. Maj a,*, Svetlana Heyte b, Marcia Araque b, Franck Dumeignil b,c, Sebastien Paul b, Isabelle Suisse a,*, Francine Agbossou-Niedercorn a,* a UCCS (Unite de Catalyse et de Chimie du Solide UMR 8181), CNRS, Universite de Lille, ENSCL, Cite Scientifique, CS 90108, 59652 Villeneuve d’Ascq Cedex, France b UCCS (Unite de Catalyse et de Chimie du Solide UMR 8181), CNRS, Universite de Lille, Ecole Centrale de Lille, Cite Scientifique, CS 20048, 59652 Villeneuve d’Ascq Cedex, France c Institut Universitaire de France, 103 Boulevard Saint-Michel, 75005 Paris, France http://dx.doi.org/10.1016/j.tet.2016.01.033 0040-4020/ 2016 Elsevier Ltd. All rights reserved. For details please contact [email protected]