Protecting-Group-Free Solid-Phase Anchoring of Polyphenolic C-Glucosidic Ellagitannins and Synthesis of 1-Alkylamino-Vescalagin Derivatives with Chemspeed’s Fully Automated SYNTHESIZER

Bridging AI and self-driving laboratories, we introduce the first fully-automated, closed-loop molecular discovery cycle, exemplified by the identification of novel JAK inhibitors. With minimal human intervention, we combined AI-driven molecular design and retrosynthesis with IBM’s synthesis automation system RoboRXN and Arctoris’ Ulysses platform for automated in-vitro screening.

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Up to 220 paint samples per day go through a fully automated screening in a unique testing facility at Byk in Wesel. / Bis zu 220 Lackproben pro Tag durchlaufen ein vollautomatisches Screening in einer weltweit einmaligen Pruefanlage bei Byk in Wesel.

Selective hydrogenation plays a critical role in modern synthetic chemistry, particularly in the pharmaceutical industry, where the production of chiral molecules with high enantiomeric purity is essential for the efficacy and safety of active pharmaceutical ingredients (APIs).