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Protecting-Group-Free Solid-Phase Anchoring of Polyphenolic C-Glucosidic Ellagitannins and Synthesis of 1-Alkylamino-Vescalagin Derivatives with Chemspeed’s Fully Automated SYNTHESIZER

September 1, 2014

The C-glucosidic ellagitannins vescalagin and vescalin are among the plant polyphenols that have been shown to interact with protein targets in a specific manner. This work describes a protecting-group-free method to immobilize these protein-binding natural products on a solid support, and a functionalizing cleavage method, which is adaptable to the solution-phase synthesis of vescal(ag)in derivatives, and which advantageously permitted the preparation of 1-alkylamino derivatives of vescalagin.

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