Synthesis
Automated synthesis and parallel reaction screening across molecular and materials spaces.
Enabling complex workflows, off-road chemistry, and expanded experimental diversity through versatile automation
Automated library synthesis and parallel reaction screening of small organic molecules, large organic molecules, polymers, and inorganic materials in research (μL to mL) require complex workflows and demanding reaction conditions, such as wide temperature as well as pressure range, reflux, work-up, analytics, inertization combined with Chemspeed's unprecedented experience in versatile automated synthesis, incl. reaction preparation, synthesis, work-up / purification, and analysis.
As a result, molecular and materials diversity as well as novel "off-road chemistry" routes are often required, meaning more and more experiments, typically with the same resources.
Chemspeed provides synthesis solutions which accelerate, standardize, digitize your research, without compromise (e.g. 96/384 discrete reactions in individuals). Highly innovative technology allows mimicking virtually any synthesis workflow in a fully automated way. This saves precious time and increases the output of your lab dramatically by using concepts designed for chemist by chemists.
Synthesis example solutions
26 solutions · Page 1 of 3
High throughput peptide, oligonucleotide and oligosaccharide synthesis
Molecular diversity / large-molecule discovery in e.g. medicinal chemistry enabled by our high throughput library synthesis solutions in disposable glass vials and / or reusable double-jacket reactors and / or microwave reactors and / or photochemical glass reactors. The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our disposable glass reactors, and our user-friendly software, allow you to accelerate, standardize and digitalize your (oligo)peptide, (oligo)nucleotide and (oligo)saccharide workflows.
Matrix-to-matrix gravimetric pick & dispense of solids for catalyst screening
Paradigm shift in catalyst screening - gravimetric pick & dispense of ligands, catalyst precursors, catalysts.
High throughput library synthesis for innovative, better medicines
Automated, parallel library synthesis / lead optimization in drug discovery (medicinal chemistry).
High throughput library synthesis reaction screening with online NMR
Automated, parallel library synthesis and reaction screening with online benchtop NMR (e.g. automated synthesis, online characterization, data analysis, AI / ML closed loop).
Automated, parallel library synthesis of e.g. organics, inorganics, nanomateriales
High throughput library synthesis of organics, inorganics, and hybrid materials in disposable glass vials and / or reusable double-jacket reactors and / or microwave reactors and / or photochemical glass reactors with mixing, heating, refluxing, cooling, vacuum, inert gas.
Automated active ingredients (AI) library synthesis
Molecular diversity / molecule discovery in e.g. medicinal chemistry enabled by our high throughput library synthesis solutions in disposable glass vials and / or reusable double-jacket reactors and / or microwave reactors and / or photochemical glass reactors.
High output metal salt solution preparation, impregnantion, washing, drying
Parallel heterogeneous catalyst preparation by automated versatile impregnation such as incipient wetness, excessive liquid impregnation. You certainly face challenges in manual catalyst preparation by impregnation like:• Lack in quality and reproducibility• Lack in systematic diversity for optimization & innovation• Increasing constraints by environmental impacts and corresponding regulations
High throughput catalyst synthesis & screening in flexible well-plate formats
Unattended catalyst preparation / formation / assembly and screening at ambient and elevated pressure in verasatile 96-well plates with disposable glass vials / reactors.
High throughput organics, inorganics, polymer synthesis under superheated, accelerated conditions
Automated, parallel synthesis in verasatile 96-well plates with disposable glass vials / reactors under accelerating superheated conditions (van't Hoff rule).
Take your classical & automated synthesis to hyper speed
Life science industry faces the increased demand for innovative, “Rule of five compatible small-molecule” medicines against various diseases. Time-to-market with an easily accessible but highly innovative API is essential.Gamification of Research & Development represents a paradigm shift in life science research. It enables flexibility, diversity, standardization, and speed in the entire discovery process, i.e. synthesis, purification, sample management, reformatting and biology testing, based on an unprecedented automation concept combined with SMOLE.
Synthesis news
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Beyond Traditional RAFT Polymerization: Emerging Strategies and Future Perspectives; A Third Update
Reversible addition–fragmentation chain transfer(RAFT) polymerization has undergone transformative growth since itsinception in 1998, emerging as a powerful and versatile tool for precision polymer synthesis.
Artificial intelligence-driven autonomous laboratory for accelerating chemical discovery
Autonomous laboratories, also known as self-driving labs, have emerged as a powerful strategy to accelerate chemical discovery. By highly integrating different key parts including artificial intelligence (AI), robotic experimentation systems and automation technologies into a continuous closed-loop cycle, autonomous laboratories can efficiently conduct scientific experiments with minimal human intervention.
How AI Is Accelerating the Fight Against Climate Change
Self‑driving laboratories are transforming scientific research by combining AI, robotics, and automation to design, run, and analyze experiments autonomously.
Stable acidic oxygen-evolving catalyst discovery through mixed accelerations
Ruthenium oxides (RuOx) are promising alternatives to iridium catalysts for the oxygen-evolution reaction in proton-exchange membrane water electrolysis but lack stability in acid. Alloying with other elements can improve stability and performance but enlarges the search space.
Experimental and kinetic study of the microwave-assisted catalytic conversion of glucose
Microwave technology offers rapid, selective, and efficient heating, making it a valuable tool for process intensification. In this context, this study employed microwave energy for rapid reaction optimization and reliable kinetic analysis for the catalytic conversion of glucose. Dehydration (DeH) and retro-aldol condensation (RAC) are two main routes for the catalytic conversion of glucose into valuable platform chemicals such as levulinic acid, methyl lactate, and other byproducts.
Toward fully autonomous closed-loop molecular discovery – A case study on JAK targets
Bridging AI and self-driving laboratories, we introduce the first fully-automated, closed-loop molecular discovery cycle, exemplified by the identification of novel JAK inhibitors. With minimal human intervention, we combined AI-driven molecular design and retrosynthesis with IBM’s synthesis automation system RoboRXN and Arctoris’ Ulysses platform for automated in-vitro screening.
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