Trends in Chemistry
Multistep automated pharmaceutical syntheses have been a long-term industrial goal. Automation not only enables the rapid and highly efficient preparation of organic compounds by eliminating the physical barriers, but also endow chemists with more time for critical thinking by relieving them from laborious work. With the growing demand for fast and efficient synthesis of active pharmaceutical ingredients (APIs) for drug development, several efforts have been made in various subfields to improve the universality and capability of automation in multistep synthesis. This review highlights the recent development of automated iterative synthesis, automated digitalized batch synthesis, automated solid-phase synthesis (SPS)-flow synthesis, automated radial synthesis, as well as automated multistep continuous-flow synthesis and how they complement each other in the automated synthesis of pharmaceuticals.
For details:
Multistep automated synthesis of pharmaceuticals
Gan Wang a, Hwee Ting Ang a, Srinivas Reddy Dubbaka b, Patrick O’Neill c, Jie Wu a,d
a. Department of Chemistry, National University of Singapore, Singapore 117543, Republic of Singapore
b. Pfizer Asia Manufacturing Pte Ltd, Manufacturing Technology Development Centre (MTDC), Synapse Building, #05-17, 3 Biopolis Drive, Singapore 138623, Republic of Singapore
c. Pfizer Ireland Pharmaceuticals, Process Development Centre, Ringaskiddy (PDC), Co. Cork, Ireland
d. National University of Singapore (Chongqing) Research Institute, Chongqing, 401120, People’s Republic of China
DOI: https://doi.org/10.1016/j.trechm.2023.03.008
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FLEX ISYNTH for Library Synthesis_Small Scale
FLEX ISYNTH Library Synthesis with online NMR
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ISYNTH CATSCREEN96
ISYNTH SPEEDCHEM
ISYNTH SWAVE
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