Ruthenium-catalyzed synthesis of vinylamides at low acetylene pressures

Chemical Communications Journal

The reaction of cyclic amides with acetylene under low pressure, using ruthenium-phosphine catalysts, afforded a broad variety of N-vinylated amides including (azabicyclic) lactams, oxazolidinones, benzoisoxazolones, isoindolinones, quinoxalinones, oxazinanones, cyclic urea derivatives (imidazolidinones), nucleobases (thymine), amino acid anhydrides and thiazolidinone.

For details: Ruthenium-catalyzed synthesis of vinylamides at low acetylene pressures

Elena Semina ^a, Pavel Tuzina ^b, Frank Bienewald ^b, A. Stephen K. Hashmi ^ac and Thomas Schaub ^ab

^a Catalysis Research Laboratory (CaRLa) Im Neuenheimer Feld 584, 69120 Heidelberg, Germany

^b Organic Synthesis, BASF SE Carl-Bosch-Str. 38, 67056 Ludwigshafen, Germany

^c Organisch-Chemisches Institut, Heidelberg University Im Neuenheimer Feld 270, 69120 Heidelberg, Germany

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Chemical Communications Journal
https://doi.org/10.1039/D0CC01533D
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