Ruthenium-catalyzed synthesis of vinylamides at low acetylene pressures

Microwave technology offers rapid, selective, and efficient heating, making it a valuable tool for process intensification. In this context, this study employed microwave energy for rapid reaction optimization and reliable kinetic analysis for the catalytic conversion of glucose. Dehydration (DeH) and retro-aldol condensation (RAC) are two main routes for the catalytic conversion of glucose into valuable platform chemicals such as levulinic acid, methyl lactate, and other byproducts.

Bridging AI and self-driving laboratories, we introduce the first fully-automated, closed-loop molecular discovery cycle, exemplified by the identification of novel JAK inhibitors. With minimal human intervention, we combined AI-driven molecular design and retrosynthesis with IBM’s synthesis automation system RoboRXN and Arctoris’ Ulysses platform for automated in-vitro screening.

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Up to 220 paint samples per day go through a fully automated screening in a unique testing facility at Byk in Wesel. / Bis zu 220 Lackproben pro Tag durchlaufen ein vollautomatisches Screening in einer weltweit einmaligen Pruefanlage bei Byk in Wesel.