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Synthesis of Novel Bromodifluoromethyl(arylsulfonyl) Compounds and Nickel Catalyzed Cross Coupling with Arylboronic Acids

July 7, 2016
  • Prepared two novel bromodifluoromethyl(arylsulfonyl) compounds
  • Using high-throughput experimentation (HTE) we have identified a very challenging Suzuki type coupling reaction catalyzed by nickel, providing direct formation of Csp2-CF2SO2Ar bonds
  • We propose a CF2SO2Ar radical species is involved in the reaction pathway
  • Future work will focus on the use of a photocatalyst to improve the harsh conditions of this transformation

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Read more about Aqueous sonochemical synthesis of covalent organic frameworks
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Mar
10

Aqueous sonochemical synthesis of covalent organic frameworks

Covalent organic frameworks (COFs) are versatile materials platforms for precise function integration owing to their high crystallinity, large surface areas, tunable characteristics and diverse and predictable structures. However, the dominant solvothermal method for COF synthesis requires harsh conditions, including high temperatures, toxic organic solvents, sealed and pressurized reactors, and extended reaction times that often exceed several days.

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