News Picture Generic

Synthesis of Novel Bromodifluoromethyl(arylsulfonyl) Compounds and Nickel Catalyzed Cross Coupling with Arylboronic Acids

July 7, 2016
  • Prepared two novel bromodifluoromethyl(arylsulfonyl) compounds
  • Using high-throughput experimentation (HTE) we have identified a very challenging Suzuki type coupling reaction catalyzed by nickel, providing direct formation of Csp2-CF2SO2Ar bonds
  • We propose a CF2SO2Ar radical species is involved in the reaction pathway
  • Future work will focus on the use of a photocatalyst to improve the harsh conditions of this transformation

Other Recent News

Discover more news articles you might be interested in

Read more about High-throughput solid microsampling through stochastic robotic automation
News Picture 1 1 V2
Featured
Jul
14

High-throughput solid microsampling through stochastic robotic automation

Solid sampling at the sub-milligram and milligram scale remains a major bottleneck for high-throughput chemistry or material sciences, as existing approaches rely on manual handling or slow deterministic microsampling that do not readily scale.

Here we present STORMS, an automated STOchastic Robotic MicroSampling system that enables fast, reliable and parallel sampling of solid materials at sub-milligram and milligram masses. 

© Chemspeed (part of Bruker) 2026