Tailoring Cellular Uptake of Gold Nanoparticles Via the Hydrophilic-to-Hydrophobic Ratio of their (Co)polymer Coating

Ghent University, Belgium

Advanced Functional Materials Journal

It is demonstrated how cellular uptake and protein corona of (co)polymer-coated gold nanoparticles can be altered by the hydrophilic-to-hydrophobic comonomer ratio. A novel, label-free flow cytometry strategy is developed to investigate particle uptake. These findings offer insight in the design and analysis of hybrid nanomaterials for interfacing with biological systems.

For details: Tailoring Cellular Uptake of Gold Nanoparticles Via the Hydrophilic-to-Hydrophobic Ratio of their (Co)polymer Coating

Zhiyue Zhang*, Katleen Van Steendam*, Samarendra Maji**, Lieve Balcaen***, Yulia Anoshkina***, Qilu Zhang**, Glenn Vanluchene**, Riet De Rycke****, Frank Van Haecke***, Dieter Deforce*, Richard Hoogenboom** and Bruno G. De Geest*

* Department of Pharmaceutics Ghent University, 9000 Ghent, Belgium

** Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry, Ghent University, 9000 Ghent, Belgium

*** Department of Analytical Chemistry, Ghent University, 9000 Ghent, Belgium

**** Department of Biomedical Molecular Biology, Ghent University, 9000 Ghent, and Inflammation Research Center VIB, 9052 Zwijnaarde, Belgium

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Advanced Functional Materials Journal
DOI: 10.1002/adfm.201500904
2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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