example solution
Swing

Automated active ingredients (AI) library synthesis

ISYNTH AI
Overview

Chemspeed's solution

The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our disposable or reusable or microwave or photochemistry reactors and our user-friendly software enable you to accelerate, standardize and digitize your parallel library synthesis / work-up / analysis workflows for enabling your innovative medicine R&D. 

Chemspeed’s ISYNTH deck modularity provides unrivalled versatility to execute and perform a variety of workflows in a fully automated fashion, including reaction preparation, multistep synthesis, work-up, purification, analysis and product transfer to storage.


Workflow

Example workflow

ISYNTH AI

Benefits

Powerful advantages

  • Decrease in cost per experiment up to 90+ %.
  • Increase in productivity by a factor of 10+.
  • Easy-to-use disposable glass reactors / vials and / or reusable double-jacket reactors and / or microwave and / or photochem reactors.
  • Reagent preparation (liquids and solids), multistep synthesis, work-up, purification, analysis and product transfer to storage.
  • Ventilated, conditioned hood for e.g. sensitive, low-temperature chemistry
  • - 70 to 200 °C.
  • 4-Needle Head for volumetric liquid handling and sampling.
  • Gravimetric solid dispensing into an unlimited choice of vial / plate / reactor formats.
  • The balance moves to the destination, increasing speed and efficiency.
  • Balance resolution of 100 μg or 10 μg.
  • A large dispensing range from μg up to g.
  • Powder dispensing / dosing robotic tool can be combined with other tools to accommodate multiple workflows.
  • Dispensed amount, mixing speed, temperature, pressure, time, ... and other data are stored in a read only log file.
  • Various integrated analytics such as HPLC (MS), UPLC (MS), GC (MS), Online benchtop flow-cell NMR, offline benchtop NMR.
  • Additional integrated analytics, including online benchtop flow-cell UV-VIS, pH measuremnt & adjustment, NIR & MIR measurement cell and DLS measurement cell.
  • Exchangeable robotic tools to accommodate multiple workflows.
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface to data analysis.
  • Interface to e.g. DOE, ML, AI, LIMS, ELN, ERP.
Software
Chemspeed AutoSuite Software laptop screen