example solution

Automated small-scale / μL library synthesis

FLEX ISYNTH for library synthesis small scale
Two blue chemspeed robotic platforms in metal sitting in a white hallway

Chemspeed's solution

Molecule diversity / discovery in e.g. medicinal chemistry is driven more and more by the demand for innovative, better medicines which involves molecular diversity and novel routes, meaning more and more experiments typically with the same amount of resources.

Chemspeed’s fully automated, integrated FLEX ISYNTH stands for a flexible, modular, and uncompromising automated solution that:

  • Unlocks the chemical space via faster, better, virtually unrestricted “off-road” chemistry investigation of the Reaction space, Reagent space and Molecule space.
  • Enhances your efficiency and productivity by a factor of up to 100 in, for example: C-C, C-N coupling reactions, Organometallic reactions (e.g. Grignard), Alkylations, Diels-Alder reactions and Transfer hydrogenations.


Example workflow

FLEX ISYNTH - Library synthesis small scale


Powerful advantages

  • Fully automated, integrated reaction preparation, synthesis, work-up, analysis, output to storage vials for solid-phase and liquid-phase μL library synthesis.
  • Easy-to-use disposable multi-functional, high-precision glass reactor arrays with μL reaction scale, Screwless and self-sealing opening / closing, Mixing by shaking (up to 1'000 rpm), Heating (up to 150°C) and Cooling (-20°C).
  • Proprietary robotic tool exchange.
  • Gravimetric solid handling from μg to g.
  • Gravimetric liquid handling from μL to mL.
  • Chemistry proven liquid handling with e.g. filtration, heated needle extension.
  • Throughput, up to 48 / 96 / ... parallel reactions per run based.
  • Sampling.
  • Various integrated analytics such as HPLC (MS), UPLC (MS), GC (MS).
  • Online benchtop flow-cell NMR, offline benchtop NMR, Online benchtop flow-cell UV-VIS, pH measurement & adjustment, NIR & MIR measurement cell, DLS measurement cell.
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface to data analysis.
  • Interface to e.g. DOE, ML, AI, LIMS, ELN, ERP.
  • Ventilated hood for safety as well as conditioned operation and trolley.
  • Optimized footprint (3x3 ft, 90x90 cm) versus capacity... all while reducing coats / maximising return on investment.
Chemspeed AutoSuite Software laptop screen