example solution

End-to-end DSC sample preparation


Chemspeed's solution

Differential scanning calorimetry (DSC) is one of the most frequently used thermal analysis techniques. DSC is used to measure enthalpy changes due to changes in the physical and chemical properties of a material as a function of temperature or time. 

The method allows you to identify and characterize materials and provides numerous applications in almost all branches of the chemical & pharmaceutical industry: compounds from APIs to polymers can be analyzed for glass transition, melting, crystallization degree, phase transition, protein denaturation and decomposition point.

Furthermore, DSC enables the investigation of chemical reactions, the influence of additives, fillers or the processing of materials. The typical shapes of the DSC curves of compounds or formulas is used for quality control. DSC is fast, very sensitive and easy to use.

However, the preparation of DSC samples with filling & closing of the crucibles is often still done manually and binds highly qualified resources to very time-consuming, tedious and error-prone tasks.

The SWILE technology enables automated true one-to-one gravimetric "pick & decision dispense" of solid compounds. The scheme at the bottom of this page displays the simplified SWILE workflow including the precision "pick & decision dispense" step. The technology backbone is based on Chemspeed’s proprietary overhead gravimetric dispensing tool design in combination with a second analytical on-deck-balance.

The modified 4-Needle Head Liquid Handling tool closes the DSC crucibles after the dispense and transports them into any kind of DSC device autosampler to provide ready-for-use DSC samples without manual interaction.

In order to exclude any risk of cross-contamination disposable glass tips are used which are stored and provided by the automated SWIN dispenser. The SWINs are available in different sizes (diameter) and can be adjusted according to the desired target amount to be dispensed. Additionally, a tilt / shake rack is used to loosening up and tilting the powder prior to pick-up. 


Example workflow



Powerful advantages

  • Revolutionary accuracy & precision due to decision dispensing.
  • Dispensing range from <100 μg to about 5 mg with +/- 10 μg resolution.
  • No cross-contamination.
  • No dead volume.
  • Unattended operation.
  • Fully inert (glass).
  • Proprietary robotic tool exchange interface.
  • Ventilated hood for safety and trolley.
  • Optimized footprint (3x3 ft, 90x90 cm) versus capacity - all while reducing costs and maximizing return on investment.
  • SWILE Robotic Tool can be combined with other tools to accommodate multiple workflows.
  • On-deck balance, tilt / shake rack, barcode reader, multigripper.
  • Automated sample dispensing into DSC crucibles (optional on-deck balance for 10 μg resolution).
  • Automated lid placement and crucible closure.
  • Reformatting of closed crucibles into DSC autosampler rack (a variety of different autosampler racks can be implemented).
  • AUTOSUITE SOFTWARE - drag & drop experimentation with easy interface to data analysis.
  • Interface for e.g. LIMS, ELN integration.
Chemspeed AutoSuite Software laptop screen