Ligand, catalyst precursor and catalyst distribution / reformatting from the libraries into reaction screening plates is often still done manually and binds highly qualified resources to very time-consuming, tedious, and error-prone tasks.
The SWILE technology provides fully automated true one-to-one gravimetric "pick & decision dispense" of catalysts. The scheme at the bottom of this page displays the simplified SWILE workflow including the precision "pick & decision dispense" step. The technology backbone is following Chemspeed’s proprietary overhead gravimetric dispensing tool design in combination with a second analytical on-deck-balance.
In order to exclude any risk of cross-contamination disposable glass tips are used which are stored and provided by the SWIN dispenser. The SWINs are available in different sizes (diameter) and can be adjusted according to the desired target amount to be dispensed. Additionally, a tilt / shake rack is used to loosening up and tilting the solid prior to pick-up.
The interactive workflow panel below showcases example workflows for this solution. Each Chemspeed tool or module performs a set of specific actions, as in any manual lab workflow, and an almost limitless arrangement of these tools is possible.
Chemspeed’s AUTOSUITE software packages execute and control all modules in every solution. They control all Chemspeed robotic platforms and any other integrated 3rd-party software and hardware.