Life science industry faces the increased demand for innovative, “Pfizer’s rules compatible small-molecule” medicines against various diseases. Time-to-market with an easy accessible but highly innovative API is essential. Gamification of Research & Development represents a paradigm shift in life science research. It enables flexibility, diversity, standardization, and speed in the entire discovery process, i.e. synthesis, purification, sample management, reformatting and biology testing based on an unprecedented automation concept combined with SMOLE.