Germany – June 2018
”We are using our Chemspeed SWILE Catalyst Dispensing solution for the production of screening kits for cross coupling reaction such as Suzuki or Buchwald reactions. The system took over all our manual and tedious weighing tasks of small quantities between 1 and 3.5 mg. It produces reaction kits for screening reactions in 96-well format which can be used in our fully automated ISYNTH screening platform.”
GIT Laborfachzeitschrift – Ausgabe 2, Februar 2017
Das präzise Einwiegen / Dosieren / Umformatieren von Feststoffen ist ein essenzieller Arbeitsschritt im Laboralltag. Speziell bei Untersuchungen der biologischen oder katalytischen Aktivität stellt das Einwiegen / Umformatieren von Kleinstmengen von Feststoffen eine Herausforderung dar. Es handelt sich um eine sehr zeitaufwendige, monotone und fehleranfällige Tätigkeit.
Zusätzlich wird die Aufgabe durch den Umstand erschwert, dass oft nur sehr geringe Sub-stanzmengen vorhanden sind und / oder kleinste Mengen eingewogen werden müssen. Die SWILE Technologie wurde genau für diesen Aufgabenbereich entwickelt und ermöglicht erstmals das vollautomatisierte Einwiegen von Kleinstmengen im Bereich von <100 µg bis 100 mg ohne vorheriges Umformatieren, also direkt aus praktisch jedem Behältnis heraus. Das System stellt somit die erste komplett automatisierte Lösung für das 1:1 Umformatieren von Feststoffen (Matrix-zu-Matrix / Tochtermatrix) dar.
‘’The FLEX FORMAX is derived from the FORMAX that proved its essential use and success in our laboratories for the past 10 years: improved productivity, quality, traceability and scalability!’’
‘’Automation of our foundation formulations has provided a significant gain of time once the initial color definition has been established and iterations and fine tuning are needed. An estimated increase of productivity by a factor of three was fulfilled thus considerably reducing the Time to Market. Notable and important point is the excellent reproducibility of the Chemspeed Technologies automated foundation formulation solution leading to exploitable scalable formulations for our development and pilot activities.’’
January 2018 – The Laboratory of Molecular Simulation (LSMO) at EPFL Valais Wallis
“The Laboratory of Molecular Simulation (LSMO) at EPFL has selected Chemspeed Technologies in order to accelerate their research work in discovering novel nanoporous materials. The overarching goal of this project is to identify a ‘wonder’ material that can outperform existing materials reported and available in the market for energy, environmental and sensing applications!
High-throughput methods represent a very promising approach for accelerating the discovery of metal-organic frameworks (MOFs) as a large number of automated and integrated reactions can be prepared in one batch by screening a wide variety of parameters: metal source and solvent mixtures, concentrations, ratio between the metal and ligand, pH of the reaction, heating temperature, time and others. The utilization of RoSy (Robotic Synthesiser ISYNTH SWAVE) at EPFL Valais Wallis is an ideal tool for the discovery of new materials as it allows the LSMO researchers to run a series of 50 (or more) simultaneous experiments for the synthesis of MOFs (automated dispensing of solids – ligands, metal salts and liquids with high quality; automated capping and crimping of the reaction vials without manual interference; microwave heating; confirmation of the product formation with the integrated camera). The experimental results (successful and failed) are then utilized to rank each synthetic reaction with the Genetic Algorithms (GAs) – an approach that the computational scientists in LSMO have developed. After this ranking, a set of new synthetic conditions is generated and run experimentally using RoSy. This can lead in multiple generations of MOFs (set of 50 reactions) and it continues until the best conditions are identified. Recent advances from this research activity include the discovery of new MOFs and the optimisation of the synthetic conditions for the synthesis of stable, originally reported as unstable MOFs. Additionally by establishing this robust iterative method, the design and synthesis of specific MOF for the capture / storage of strategically critical gases (CH4, CO2, H2) can be achieved!”
December 2017 – French National Institute for Agricultural Research, BIBS Platform
The French National Institute for Agricultural Research (INRA) is celebrating its 5th successful year of automating demanding sample preparation/derivatization with Chemspeed technology!
INRA is Europe’s top agricultural research institute and the world’s number two centre for the agricultural sciences. Its scientists are working towards solutions for society’s major challenges. The Biopolymères, Biologie Structurale (BIBS platform) – of INRA, Nantes, France is part of Biopolymers Interactions Assemblies (BIA) of the characterization and development of agricultural products (CEPIA).
BIBS has been certified ISO 9001 and is recognized as a strategic platform of INRA. The Chemspeed’s SWING system is at the heart of the BIBS platform and is being used for the automation of demanding sample preparation/derivatization workflow campaigns for screening structural properties of agricultural derived biopolymers.
Sophie Le Gall of INRA states, “The Chemspeed system allows us to perform more sample preparation screening campaigns while freeing up our staff from very constraining and repetitive manipulations that require the use of highly toxic chemicals. In addition, the system eliminates analyst to analyst variation and performs highly complex chemical synthesis-like sample preparations that only highly trained staff can manage.”
Sutheerawat Samingprai, R&D-Scale-up and Process technology, states: “It is known that research is a seriously tough job, it e.g. always needs to satisfy the expectation of every people and management level involved. Moreover, it always takes time. Normally, it might take around 10 years from laboratory scale to commercial scale. Besides, in polyolefin research it is more than 60% of the whole journey that falls into lab scale phase. Nowadays, more and more automation is involved and relieves such constraints. Thus, I am very pleased to expand the implementation of high-output research in PTT Global Chemical Limited (Public), Thailand. Chemspeed Technologies has been an excellent company providing us a convincing solution for the highly challenging automated polyolefin catalyst synthesis, catalyst screening, and polymerization testing. I believe that these tools will provide a strategic advantage to our R&D organization in our effort to rapidly develop novel polyolefin products for local and global use. In addition to accelerating and standardizing experimentation, the Chemspeed solution also enables R&D data preservation and evolution in one informatics platform which will help PTTGC researchers to be more productive and innovative.”
Clariant, Frankfurt, Germany
“To help reduce the time to market for new products, Group Technology & Innovation has developed an advanced laboratory centered on high throughput experimentation (HTE) techniques. The lab provides accelerated synthesis, formulation, application and testing for all business units across the product landscape.
Accelerating the development of new products and reducing their time to market is a critical factor in Clariant’s success. Developing a product often requires multiple formulations and testing, making this process very labor-intensive and time-consuming.
To accelerate scientific research, Clariant has set up a central High Throughput Experimentation (HTE) laboratory at its Clariant Innovation Center (CIC) in Frankfurt-Hoechst, Germany. HTE uses automated instrumentation, specialized software tools, and alternative research techniques to increase the output of experimentation, application, and testing, all of which help improve the efficiency and productivity of the development process.“
Oil & Gas Science and Technology – Rev. IFP Energies nouvelles
Catalysis, irrespective of its form can be considered as one of the most important pillars of today’s chemical industry. The development of new catalysts with improved performances is therefore a highly strategic issue. However, the a priori theoretical design of the best catalyst for a desired reaction is not yet possible and a time- and money-consuming experimental phase is still needed to develop a new catalyst for a given reaction.
Reaction Chemistry & Engineering, The Royal Society of Chemistry
Knochel – Hauser bases, derived from 2,2,6,6-tetramethylpiperidinyl (TMP) metal amides, offer exceptional selectivity and functional group tolerance in the regioselective metalation of arenes and heteroarenes. The selectivity, stability and yield of these reactions are highly dependent on the nature of the base, additive and deprotonation temperature.