Sanofi R&D; High-Throughput Experimentation for Reaction Optimization in Medicinal Research

Covalent organic frameworks (COFs) are versatile materials platforms for precise function integration owing to their high crystallinity, large surface areas, tunable characteristics and diverse and predictable structures. However, the dominant solvothermal method for COF synthesis requires harsh conditions, including high temperatures, toxic organic solvents, sealed and pressurized reactors, and extended reaction times that often exceed several days.

Reversible addition–fragmentation chain transfer(RAFT) polymerization has undergone transformative growth since itsinception in 1998, emerging as a powerful and versatile tool for precision polymer synthesis.

In modern pharmaceutical and bioprocess manufacturing environments, automation alone is no longer enough. True digital transformation requires every instrument, robot, sensor, and workflow to operate with precision, reliability, and complete data integrity.