Process Research
Quality by design (QbD) and proven acceptable range (PAR)–driven solutions for accelerated, standardized, and digitized process research and chemical development.
Mimicking industrial production with flexible, integrated optimization
Process development aims at truly mimicking the final industrial production process (incl. reaction preparation, chemical reaction, work-up, analysis). Integrated reaction sequences regarding a number of critical process parameters have to be optimized simultaneously and requires a high degree of flexibility.
Chemspeed’s automated solutions have been designed for high output experimentation in the development, optimization and scale-up of chemicals. This cutting-edge technology allows scientists to execute reaction screening and development workflows in a fully automated fashion:
- Gravimetric solid and liquid dispensing
- Independent control of all process parameters in each reactor
- PAT like IR, NMR, UV-VIS, PSD, calorimetry, pH
- Feeding (gas, liquefied gas, liquid) and sampling under reaction conditions
- Cleaning in place (e.g. automated cleaning, inserts)
- Easy access to all process data with a convenient interface into Excel or virtually any other software
- Closed loop by interfacing with e.g. AI, ML, DOE
Process research example solutions
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Take your classical & automated synthesis to hyper speed
Life science industry faces the increased demand for innovative, “Rule of five compatible small-molecule” medicines against various diseases. Time-to-market with an easily accessible but highly innovative API is essential.Gamification of Research & Development represents a paradigm shift in life science research. It enables flexibility, diversity, standardization, and speed in the entire discovery process, i.e. synthesis, purification, sample management, reformatting and biology testing, based on an unprecedented automation concept combined with SMOLE.
High output polyolefin / rubber catalyst synthesis, work-up, analysis
Automated, quality assured, scalable polyolefin and rubber catalyst synthesis (Ziegler-Natta, single-site).
High output (mixed) oxide synthesis by pH-controlled precipitation, ion exchange, sol-gel processes
End-to-end automated (mixed) oxide synthesis by pH-controlled precipitation, ion exchange, sol-gel processes, incl. reaction preparation, synthesis, washing, drying for e.g. refinery catalysts, adsorbents, cathode materials.
High output process research / chemical development / scale-up
Quality by design (QbD), proven accetable range (PAR) driven automated process R&D / chemical development, scale-up and preparative synthesis.
High output porous materials synthesis, work-up, analysis
Accelerated, standardized, digitized automated zeolite and metallorganic framework (MOF) synthesis and work-up by precisely controlled hydro- and solvothermal synthesis.
Automated chemical development for organics, inorganics, polymers
Quality by design (QbD), proven accetable range (PAR) driven high output process R&D / chemical development and preparative synthesis.
Automated process R&D and preparative synthesis
Quality by design (QbD), proven accetable range (PAR) driven high-output process R&D / chemical development, preparative synthesis, work-up, and analysis.
Parallel, high output real time calorimetry
Parallel, automated and real-time calorimetry in high-precision Qbd process reactors for e.g. safety.
Automated fuel cell catalyst & membrane discovery and optimization
The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our quality by design reactor as well as process excellence and user friendly software enable you to accelerate, standardize and digitalize your fuel cell catalysts and membrane discovery / optimization as well as optimization workflows.
Automated batch & flow chemistry
Automated all-in-one batch and / or flow chemistry with independent, precise process parameter control in each reactor, multistep reactions and workup with optional online benchtop NMR.
Process research news
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Machine learning can guess how well a reaction will perform, but it rarely explains why.
Machine learning can guess how well a reaction will perform, but it rarely explains why.
Catalysts on a dimmer switch. A self-driving lab finds them on its own.
Finding the right homogeneous catalyst is one of the slowest jobs in chemistry.
Mapping the crystallization landscape of rare earth MOFs. How automation turned trial-and-error into a map.
The problem / story MOF discovery has long run on manual synthesis and educated guessing.
Self-Driving Labs Are Rewriting the Clock on Discovery
North Carolina State University Now Runs the Largest Academic Self-Driving Lab Ecosystem in the US.
High-throughput solid microsampling through stochastic robotic automation
Solid sampling at the sub-milligram and milligram scale remains a major bottleneck for high-throughput chemistry or material sciences, as existing approaches rely on manual handling or slow deterministic microsampling that do not readily scale. Here we present STORMS, an automated STOchastic Robotic MicroSampling system that enables fast, reliable and parallel sampling of solid materials at sub-milligram and milligram masses.
Integration of Machine Learning and Automated Synthesis for Accelerated Drug and Material Research
The challenges posed by global climate change and disease risks have intensified the demand for efficient and practical materials and molecules. Traditional trial-and-error approaches are becoming increasingly inefficient and resource-intensive. The rapid advancement of artificial intelligence (AI) has opened new avenues to accelerate research and shorten development cycles.
From innovation to quality, Chemspeed delivers automation & digitalization that grows with your lab.
Chemspeed is a global team committed to enable automated and digitalized workflows for scientists in R&D and QC.
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