Process Research
Quality by design (QbD) and proven acceptable range (PAR)–driven solutions for accelerated, standardized, and digitized process research and chemical development.
Mimicking industrial production with flexible, integrated optimization
Process development aims at truly mimicking the final industrial production process (incl. reaction preparation, chemical reaction, work-up, analysis). Integrated reaction sequences regarding a number of critical process parameters have to be optimized simultaneously and requires a high degree of flexibility.
Chemspeed’s automated solutions have been designed for high output experimentation in the development, optimization and scale-up of chemicals. This cutting-edge technology allows scientists to execute reaction screening and development workflows in a fully automated fashion:
- Gravimetric solid and liquid dispensing
- Independent control of all process parameters in each reactor
- PAT like IR, NMR, UV-VIS, PSD, calorimetry, pH
- Feeding (gas, liquefied gas, liquid) and sampling under reaction conditions
- Cleaning in place (e.g. automated cleaning, inserts)
- Easy access to all process data with a convenient interface into Excel or virtually any other software
- Closed loop by interfacing with e.g. AI, ML, DOE
Process research example solutions
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Take your classical & automated synthesis to hyper speed
Life science industry faces the increased demand for innovative, “Rule of five compatible small-molecule” medicines against various diseases. Time-to-market with an easily accessible but highly innovative API is essential.Gamification of Research & Development represents a paradigm shift in life science research. It enables flexibility, diversity, standardization, and speed in the entire discovery process, i.e. synthesis, purification, sample management, reformatting and biology testing, based on an unprecedented automation concept combined with SMOLE.
High output polyolefin / rubber catalyst synthesis, work-up, analysis
Automated, quality assured, scalable polyolefin and rubber catalyst synthesis (Ziegler-Natta, single-site).
High output (mixed) oxide synthesis by pH-controlled precipitation, ion exchange, sol-gel processes
End-to-end automated (mixed) oxide synthesis by pH-controlled precipitation, ion exchange, sol-gel processes, incl. reaction preparation, synthesis, washing, drying for e.g. refinery catalysts, adsorbents, cathode materials.
High output process research / chemical development / scale-up
Quality by design (QbD), proven accetable range (PAR) driven automated process R&D / chemical development, scale-up and preparative synthesis.
High output porous materials synthesis, work-up, analysis
Accelerated, standardized, digitized automated zeolite and metallorganic framework (MOF) synthesis and work-up by precisely controlled hydro- and solvothermal synthesis.
Automated chemical development for organics, inorganics, polymers
Quality by design (QbD), proven accetable range (PAR) driven high output process R&D / chemical development and preparative synthesis.
Automated process R&D and preparative synthesis
Quality by design (QbD), proven accetable range (PAR) driven high-output process R&D / chemical development, preparative synthesis, work-up, and analysis.
Parallel, high output real time calorimetry
Parallel, automated and real-time calorimetry in high-precision Qbd process reactors for e.g. safety.
Automated fuel cell catalyst & membrane discovery and optimization
The leading technology in overhead gravimetric dispensing / dosing (patented) combined with our quality by design reactor as well as process excellence and user friendly software enable you to accelerate, standardize and digitalize your fuel cell catalysts and membrane discovery / optimization as well as optimization workflows.
Automated batch & flow chemistry
Automated all-in-one batch and / or flow chemistry with independent, precise process parameter control in each reactor, multistep reactions and workup with optional online benchtop NMR.
Process research news
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Autonomous Synthesis and Inverse Design of Electrochromic Polymers with High Efficiency and Accuracy
The design and synthesis of functional polymers, aimed at targeted properties through specific structures, have long been challenged by their complex and often nonlinear structure− property relationships. Key processes, including knowledge accumulation for predictive design and experimental refinement and validation, are traditionally labor-insensitive and timeconsuming, making it difficult to balance accuracy and efficiency.
Accelerating Porosity Assessment in Solid Materials via SemiAutomated Platforms
The design and discovery of porous materials have become a central theme in materials science, driven by their applications in gas storage, separation, carbon capture, and catalysis. Rapid advances in synthetic chemistry, particularly in metal–organic frameworks, porous organic cages, and conjugated microporous polymers, have enabled the generation of increasingly large and diverse material libraries.
Implementation of Large-Scale Multi-Reactor Automation for Process Development
Pharmaceuticals increasing complexity requires longer synthesis with unique processes for each step, increasing the number of experiments to develop robust sustainable processes. The time to develop these processes is getting shorter, and automation can support the growing need to efficiently perform more experiments.
Toward fully autonomous closed-loop molecular discovery – A case study on JAK targets
Bridging AI and self-driving laboratories, we introduce the first fully-automated, closed-loop molecular discovery cycle, exemplified by the identification of novel JAK inhibitors. With minimal human intervention, we combined AI-driven molecular design and retrosynthesis with IBM’s synthesis automation system RoboRXN and Arctoris’ Ulysses platform for automated in-vitro screening.
Asymmetric hydrogenation of olefins with transition metal-based catalysts: practical insights from screening to production of APIs
Selective hydrogenation plays a critical role in modern synthetic chemistry, particularly in the pharmaceutical industry, where the production of chiral molecules with high enantiomeric purity is essential for the efficacy and safety of active pharmaceutical ingredients (APIs).
Chemspeed & Ames National Laboratory: Driving Innovation Together in DOE’s Genesis Mission
We are proud to spotlight our partnership with Ames National Laboratory, a key leader in the U.S. Department of Energy’s historic Genesis Mission—an initiative harnessing the power of Artificial Intelligence (AI) to transform American science and innovation.
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