Institute of Biomaterial Science and Center for Regenerative Therapies (Helmholtz-Zentrum Geesthacht) reports on High-Throughput Synthesis and Characterization of Polymer Libraries with Chemspeed’s Fully Automated SYNTHESIZER
Diffuse reflectance FTIR (DRIFT) was established as a high throughput characterization method for classic copolymer systems. Four different methyl methacrylate-based polymer libraries with styrene, N-vinylpyrrolidone, 4-vinylpyridine, or 2-carboxyethyl acrylate as comonomers were synthesized using an automated/robotic synthesizer platform, and analyzed by ¹H NMR and DRIFT. By multivariate data analysis both data sets were compared and correlations with R² between 0.9373 and 0.9971 could be achieved. By this means high throughput screening of comonomer contents of these polymer libraries was enabled.
High Throughput Characterization of Polymer Libraries by Diffuse Reflectance Infrared Spectroscopy
Stefan Baudis, Andreas Lendlein, Marc Behl*
Berlin-Brandenburg Center for Regenerative Therapies, Helmholtz-Zentrum Geesthacht GmbH, Institute of Biomaterial Science, Kantstrasse 55, 14153 Teltow, Germany
Macromol. Mater. Eng. 2014, DOI: 10.1002/mame.201400073
About Berlin-Brandenburg Center for Regenerative Therapies
The BCRT was established as an interdisciplinary translational center with the goal of enhancing endogenous regeneration by cells, biomaterials, and factors which can be used to develop and implement innovative therapies and products. The primary focus of the BCRT is on diseases of the immune system, the musculoskeletal system and the cardiovascular system for which currently only unsatisfactory treatment options are available. At the BCRT clinicians and researchers are working closely together on the medicine of the future: Targeted, personalized medicine that depends on the early recognition of patients’ individual healing potential.